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Possible Interaction: Adenosine and Pentostatin



Research Papers that Mention the Interaction

The five day schedule was … studies had indicated that although pentostatin had an elimination half-… hours and could inhibit plasma adenosine deaminase activity for 24 hours, recovery of enzyme activity rapidly took place and accumulation … a toxic effect on non-replicating lymphoid cells could be increased by repeated dosing.
Investigational New Drugs  •  2004  |  View Paper
Functional studies of murine hypoxia revealed inhibition of ADA with deoxycoformycin (dCF) enhances protective responses mediated by adenosine (vascular leak and neutrophil accumulation).
Blood  •  2006  |  View Paper
Cordycepin but not adenosine or 29-deoxyadenosine inhibited the methylation of nuclear RNA in the presence of 29-deoxycoformycin.
Molecular pharmacology  •  1980  |  View Paper
Combinations of deoxycoformycin (l μg/ml) and either adenosine or deoxyadenosine gave growth inhibition in all three systems.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
The combination of 2'deoxycoformycin and adenosine removed not only all antigenically detectable T cells, but also functionally detectable cells, as judged by response to mitogens.
The combination of 2'deoxycoformycin and adenosine was found to have opposite effects on T lymphocytes and hemopoietic progenitors, i.e., the latter were preserved whereas the growth of T lymphocytes was inhibited following prolonged (4-7 days) incubation in suspension culture.
Human immunology  •  1988  |  View Paper
Inhibition of the erythrocytic nucleoside transport system by dilazep (1 microM) or dipyridamole (10 microM), or blockade of Ado metabolism by 2'-deoxycoformycin (5 microM) plus 5-iodotubercidin (10 microM), evokes the antiaggregatory action of Ado in whole blood (IC50 congruent to 2 microM).
Thrombosis research  •  1986  |  View Paper
Exposure of DU.528 cells to a variety of agents induced myeloid maturation; adenosine and deoxyadenosine, in the presence of deoxycoformycin , induced expression of myeloid differentiation antigens.
The Journal of experimental medicine  •  1985  |  View Paper
Combinations of deoxycoformycin and adenosine or deoxyadenosine gave inhibition of 3H-thymidine incorporation in both lymphocytes and cell lines.
Pediatric Research  •  1985  |  View Paper
dCF decreases this production by 75 % and provokes an accumulation of Ado , demonstrating a dephosphorylation of AMP.
Pediatric Research  •  1985  |  View Paper
erythro-9-(2-Hydroxy non-3-yl) adenine … a competitive inhibitor, with Ki 15 nM. Deoxycoformycin inhibits deamination … both adenosine and deoxyadenosine, with an apparent Ki of 60-90 pM. A specific antibody was developed against the purified enzyme, and a sensitive radioimmunoassay for adenosine deaminase protein is described.
The Biochemical journal  •  1981  |  View Paper
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