“Bronchoconstrictor responses to adenosine elicited 3 h following ovalbumin challenge were markedly and dose-dependently reduced by wortmannin given intratracheally (i. t.), 1 h prior to or 2 h post-allergen challenge.”
“Plasma histamine and 5-HT levels increased in response to adenosine given 3 h following ovalbumin challenge.”
“The bronchoconstrictor response to adenosine in the actively sensitised Brown Norway rat is markedly augmented following low level allergen ( ovalbumin ) challenge.”