Possible Interaction: Adenosine and Nitroprusside

“ Adenosine and SNP were infused intravenously in random order over 20 min, leaving a 30‐min control period in between.”

“The release of adenosine was markedly potentiated at both ages by the NO-producing compounds S-nitroso-N-acetylpenicillamine, sodium nitroprusside , and hydroxylamine.”

“These data suggest that these behavioral effects of sodium nitroprusside are at least partially mediated by adenosine in the striatum and hippocampus, probably via adenosine A(2A) receptors.”

“In chronically (8 weeks) infarcted hearts, maximal vasodilation in response to administered adenosine and nitroprusside , as well as to endogenously released vasodilators during reperfusion, was decreased, suggesting impaired cardiac perfusion.”

“4 Pretreatment with adenosine also potentiated the cyclic GMP response to sodium nitroprusside , abolishing the decline in [3H]‐cyclic GMP observed with sodium nitroprusside alone, and allowing [3H]‐cyclic GMP levels to be maintained for at least an additional 10 min.”

“BDM was given 20 min before hypothermia, during hypothermia (3.8 degrees +/- 0.1 degree C) … 22 h, and for 30 min after rewarming to 37 degrees +/- 0.1 degree C; ADE was … with NP for only 20 min before and during rewarming and for 30 min after rewarming.”

“CF (controls 6.0 +/- 0.5 ml/g/min) decreased less with BDM + ADE + NP (77 +/- 4% of control) than with BDM alone (60 +/- 5%) or without BDM (53 +/- 6%).(ABSTRACT TRUNCATED AT 250 WORDS)”