Possible Interaction: Adenosine and Nitroarginine

“Simultaneous administration of L-NNA and adenosine (which restored initial diameter, i.e. length of smooth muscle) restored--in part--the pressure-induced reduction in ND, reversed the pressure-induced behavior of WS to control, but not that of ID.”

“5 The NO synthase inhibitor Nω‐nitro‐L‐arginine (LNNA), which did not affect IS (IS=62±3%), attenuated the protection by ADO (IS=56±3%; P<0.05 vs ADO, P=NS vs LNNA).”

“ l-NNA inhibits the vasodilatory effects of acetylcholine, serotonin and adenosine.”

“Administration of adenosine restored the initial diameter in the presence of l-NNA , but the increase in diameter to lower pressures and the decrease in diameter to higher pressures observed under control conditions remained greatly inhibited.”

“In contrast, in the … and shorter hypoperfusion when adenosine … l-NNA and elevated K+.Conclusion: The results of this study suggest that adenosine, like other vasodilators, is unable to antagonize …/astroglial depolarization wave when the NO concentration is reduced and K+ is elevated but shortens the hypoperfusion phase significantly.”

“ N-LA , L-NAME and glibenclamide attenuated the effects of adenosine at doses of < 2.5 μM/ kg/min and pinacidil potentiated its effects.”

“Consistent with isolated heart data, the NOS inhibitors, l -NMMA (100 microm) and L-NNA (500 microm) attenuated the effect of adenosine on beta -I(Ca,L)by 69+/-8% (P<0.001, n=16) and 69+/-7% (P<0.001, n=10), respectively.”

“ N-nitro-L-arginine (100 microM) blocked the LM-609 (100%) and adenosine (60%) remote dilations.”

“Similarly, prior administration of NO synthase inhibitor NG-monomethyl-L-arginine or NG-nitro-L-arginine methyl ester significantly attenuated the depressive and bradycardic effects of adenosine.”

“Intrastriatal L-arginine decreased, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester, increased basal adenosine levels.”