Possible Interaction: Adenosine and Nitric Oxide

“Conclusions The use of adenosine infusion in combination with inhaled nitric oxide may be a potentially valuable therapeutic option for the treatment of pulmonary hypertension of the newborn.”

“The release of adenosine is also increased by NO suggesting the synchronous release of ATP.”

“ Adenosine also activates the A2 receptor that increases NO production, leading to medullary vasodilatation which is induced by activation of endothelin-B receptor and G-protein coupled E-prostanoid receptor 2, and 4 of prostaglandin PGE2 respectively as well.”

“The addition of adenosine to microvascular endothelial cells induced an increase in NO and prostacyclin levels.”

“These findings provide novel insight into the role of adenosine in skeletal muscle blood flow regulation and vascular function by revealing that both interstitial and plasma adenosine have a stimulatory effect on NO and prostacyclin formation.”

“By glutamate receptors and physiological action of nitric oxide, cyclic guanisine-5-monophosphate may be rapidly increased.”

“ Nitric oxide (NO), generated by the neuronal isoform of nitric oxide synthase in macula densa cells, reduces the constrictor effect of adenosine , but the regulation of NO release and its exact role in states of TGF-induced hyperfiltration are still unclear.”

“ Adenosine inhibits neurotransmission to the rat prostate, and NO is inhibitory in prostate from human, rat, rabbit, pig and dog.”

“Other factors impacting on the activity of NO include estrogens, endothelins, adrenomedullin and adenosine , the last appearing to be a compensatory pathway for coronary control in the presence of NO inhibition.”

“We have previously reported that adenosine stimulates the production of NO from porcine carotid arterial endothelial cells (PCAEC) via a receptor-mediated mechanism.”

“CONCLUSIONS These results indicate that the inhibition of NO sy nthesis increases both ade nosine production an d ecto5'-nucleotidase activity through the activation of PKC and that NO modulates ecto-5'-nucleotidase via cGMP-independent mechanisms.”