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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
Research Papers that Mention the Interaction
“In addition, treatment with adenosine upregulated the expression and the maximal binding capacity of muscarinic acetylcholine receptor, which were inhibited by the selective A1 adenosine receptor antagonist 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) and the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME).”
The Role of Muscarinic Receptors in the Beneficial Effects of Adenosine against Myocardial Reperfusion Injury in Rats“The retinal vasodilator responses to adenosine and acetylcholine observed in diabetic rats were diminished by NG-nitro-l-arginine methyl ester.”
“Endothelial removal or N(G)-nitro-L-arginine methyl ester (L-NAME) inhibited the dilation to adenosine by approximately 50%; subsequent addition of glibenclamide was without effect.”
“High concentrations of L-NAME blocked vasomotion, and control experiments (n = 20) using 8-Br-cGMP, S-nitroso-N-acetylpenicillamine (SNAP), adenosine and pinacidil were carried out to elucidate whether this effect was related to changes in the general tone of the vessel.”
“ L-NAME significantly reduced the inhibitory responses induced by the lower (3 x 10(-8)-3 x 10(-7) M) concentrations of adenosine.”
“The results obtained are as follows: (1) injection of 50, 100, and 200 nmol/kg adenosine into the renal artery increased the renal afferent … antagonist, partly abolished the effect of adenosine; and (3) pretreatment with a nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methylester L-NAME, … adenosine.”
“Intracoronary infusions of acetylcholine (ACh), Adenosinc (Ado), bradykinin (Bk), and papaverine (Pap) caused dose-dependent increases in CDLC and CE Infusion of l-NAME nearly abolished the dilator effect of Ado on CDLC and reduced those to ACh, Bk and Pap.”
“ Nomega-nitro-L-arginine methyl ester shifted the dose-response curves of adenosine , N6-cyclopentyladenosine, or 5'-N-ethylcarboxamidoadenosine to the right in both normal and hypothyroid vessels.”
“Combined application of adenosine and L-NAME led to a dramatic increase of V, VUNa, VUCl and Ccr in intact rats.”
“ L-NAME decreased aortic sensitivity to adenosine in immature and mature tissues but was ineffective in the moderately aged aorta.”
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