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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Neuropeptide Y
Research Papers that Mention the Interaction
“ NPY was at least 200-fold more potent than norepinephrine or adenosine to produce an equivalent inhibition.”
Neuropeptide Y (NPY), an endogenous presynaptic modulator of adrenergic neurotransmission in the rat vas deferens: Structural and functional studies“The evoked release of NPY was also attenuated by ATP and adenosine , which have been shown to be colocalized and coreleased with NPY from sympathetic nerve terminals.”
Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors.“We examined the role of adenosine in modulating the coronary constrictor effect of neuropeptide Y (NPY).”
“In cerebral arteries contracted with histamine, adenosine , and acetylcholine-induced relaxation was inhibited by 7-14-fold in the presence of 1.5 nM NPY , with no change in maximal relaxation.”
“Ouabain and ouabain plus NPY also decreased the maximal relaxant effect of adenosine.”
“After half-maximal contraction of coronary arteries with histamine and addition of 30 nM NPY , relaxation produced by norepinephrine (in the presence of 3 μM phentolamine), adenosine , and acetylcholine was inhibited.”
“The evoked release of NPY was also attenuated by ATP and adenosine , which have been shown to be colocalized and coreleased with NPY from sympathetic nerve terminals.”
Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors.
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