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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Adenosine
Research Papers that Mention the Interaction
“Indeed, levels and efflux of adenosine from brain slices are markedly increased by depolarizing agents , electrical stimulation, or glutamate (Shimizu et al., 1970ri: Huang et al., 1973: Pull and McIlwain, 1973; 1975; Huang and Daly, 1974).”
Depolarization‐Evoked Accumulation of Cyclic AMP in Brain Slices: The Requisite Intermediate Adenosine is Not Derived from Hydrolysis of Released ATP“Recently, ATP and adenosine were shown to modulate the frequency of giant depolarizing potentials and spontaneous postsynaptic potentials in the newborn rat hippocampus via P2X-subclass andenosine A1 and, presumably, ATP receptors [6, 7].”
Purinergic P2X4 Receptors Are Involved in the Modulation of Giant Depolarizing Potentials in the Hippocampus of Newborn Rat“2 Adenosine dose dependently and reversibly inhibited ICa elicited by depolarizing voltage steps from a holding potential of ‐80 mV to potentials ranging from ‐30 to +20 mV. The mean (± s.e.m.)”
“The combination of adenosine with depolarizing agents showed an additive effect on the level of guanosine 3',5'-monophosphate indicating that adenosine increased the level of guanosine 3',5'-monophosphate by a different mechanism from the depolarization.”
“It has been proposed that electrical pulses and elevated levels of K+ ions and other ' depolarizing '' stimuli act to increase adenosine 3' , 5'-monophosphate (cyclic AMP) levels in brain tissue via release and subsequent action of adenosine.”
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