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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Nerve Growth Factor
Research Papers that Mention the Interaction
“Second is discussed how adenosine is able to prevent or delay apoptosis in more mature sympathetic neurons subjected to nerve growth factor deprivation in culture.”
Intracellular, nonreceptor-mediated signaling by adenosine: induction and prevention of neuronal apoptosis.“ Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.”
Calcineurin contributes to the enhancing effect of adenosine on nerve growth factor-induced neurite outgrowth via the decreased duration of p38 mitogen-activated protein kinase phosphorylation.“ Adenosine and CGS 21680stimulated ERK1/2, but inhibited the phosphorylation of ERK1/2 induced by a 10 min incubation with NGF.”
“The addition of 100 microM adenosine to neurite-bearing DRG neurons inhibited neurite growth by 47% after 2-day exposures in vitro and by 50% after 5 days whereas in the presence of NGF this inhibition was reduced to 28% and 32%, respectively.”
“ Adenosine (1‐100 microM) inhibited neurite outgrowth within the first 24 h and killed about 80% of sympathetic neurons supported by nerve growth factor over the next 2 days in culture.”
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