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Last Updated: 2 years ago

Possible Interaction: Adenosine and NAD

supplement:

Adenosine

supplement:

NAD

Research Papers that Mention the Interaction

Formation of adenosine from NAD+ affected UA and ATP concentrations, its main downstream molecules.
The addition of NAD+ to membranes prepared from WT mice resulted in faster generation of adenosine compared to membranes from CD38KO mice.
Molecules  •  2020  |  View Paper
Adenosine and 2-chloroadenosine, in the concentration range of 10−6–10−3 M, resulted in concentration-dependent increases in CBF and NAD reduction.
Pflügers Archiv  •  2004  |  View Paper
However, the 5′-adenine nucleotides (AMP, ADP and ATP) and NAD+ all appear to act at least partially indirectly subsequent to their hydrolysis to adenosine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Adenine dinucleotides such as beta-NAD , alpha-NAD, NADP, 3-aminopyridine adenine dinucleotide, flavin adenine dinucleotide, 3',5'-and 2',5'-adenylyladenosine mimicked the inhibitory effects of adenosine and adenine nucleotides on electrically evoked contractions of the rat and mouse isolated superfused vas deferens.
European journal of pharmacology  •  1981  |  View Paper
The adenosine derivatives, adenosine , AMP, ADP, and ADP-ribose, were found to inhibit the NADase-catalyzed hydrolysis of NAD.
The Journal of biological chemistry  •  1972  |  View Paper
Phosphoenolpyruvate (Km = 1.6 mM), adenosine 5′-triphosphate (Km = 0.5 mM), adenosine diphosphate (Km = 1.5 mM), and adenosine 5′-monophosphate (Km = 3.0 mM) are competitive inhibitors with respect to NAD+.
Journal of bacteriology  •  1973  |  View Paper
5'-Adenylic acid can inhibit both lactic dehydrogenase and glutamic dehydro-genase; since both the phosphate and adenine moieties are necessary for good in-ibition, the 5'-adenylic acid presumably competes with DPN.
Journal of pharmaceutical sciences  •  1963  |  View Paper
The synthesis of guanine from adenine riboside or ribotide occurred only in the presence of added DPN.
Archives of biochemistry and biophysics  •  1955  |  View Paper