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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Adenosine
drug:
Mycophenolic Acid
Research Papers that Mention the Interaction
“We found that the attachment of adenosine to the MPA through variety of linkers afforded numerous mycophenolic adenine dinucleotide (MAD) analogues that inhibit the two isoforms of the human enzyme in low nanomolar to low micromolar range.”
“ MPA exerts its immunosuppressive effect through the inhibition of inosine-5-monophosphate dehydrogenase.”
“Furthermore, exogenous guanosine, but not exogenous adenosine , reversed these effects induced by MPA.”
Mycophenolic acid induces islet apoptosis by regulating mitogen-activated protein kinase activation.“ Mycophenolic acid (MPA) and tiazofurin inhibit inosine-monophosphate dehydrogenase, a’ key-enzyme’ of the purine pathway.”
Compartmentation of ribonucleotides in PC-12 cells: free and protein bound ribonucleotides.“ Mycophenolic acid (10 μg ml−1) inhibited the growth of Artemia (as measured by their protein and soluble nucleotide content) in the presence of adenosine and inosine as the purine source, and had no appreciable effect in the presence of guanosine.”
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