Possible Interaction: Adenosine and Methysergide

“Compound 48/80 (condensation product of N-methyl-p-methoxyphenylethylamine with formaldehyde) induced methysergide-sensitive contractions of the parenchymal strip and potentiated adenosine; the augmented response to adenosine was blocked by methysergide.”

“The response to adenosine was markedly reduced by methysergide but not significantly altered by iralukast.”

“The augmented contractile responses to adenosine were partially blocked by the 5-HT receptor antagonist, methysergide , or the A1 receptor antagonist, DPCPX, and abolished in the presence of both antagonists.”

“The bronchoconstrictor response to adenosine was blocked selectively by methysergide , disodium cromoglycate and the broad‐spectrum adenosine receptor antagonist, 8‐SPT, but not by DPCPX or ZM 243185, selective antagonists for the A1 and A2A receptors, respectively.”

“The bronchoconstriction caused by adenosine is inhibited by atropine, methysergide , sodium cromoglycate, nedocromil sodium, and ketotifen.”

“ Methysergide (10(-7) M) prevented the contractile response to adenosine and 5-hydroxytryptamine (5-HT) without affecting that to noradrenaline.”

“The vasoconstrictor responses to adenosine , ATP, guanosine and GTP were effectively antagonized by either methysergide or reserpine, whereas those to uridine and UTP were not modified by either methysergide or phentolamine.”