Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Adenosine and Methotrexate



Research Papers that Mention the Interaction

CSF adenosine concentrations of patients receiving methotrexate , even when there was very slight or no toxicity, were greatly increased compared with control subjects (mean values of 217 and 51 nmol/L, median 175 and 52 nmol/L).
The Lancet  •  1995  |  View Paper
By use of these techniques, recent … that the cardiovascular effects of adenosine can be modulated by genetic factors (e.g. a single nucleotide polymorphism in the gene encoding for adenosine …), by metabolic factors (e.g. by the plasma homocysteine concentration), and by drugs, such as caffeine, dipyridamole, and methotrexate.
European journal of pharmacology  •  2008  |  View Paper
Adenosine can suppress the release of tumour necrosis factor-α (TNF-α) from activated monocytes and macrophages, and may contribute to the anti-inflammatory activities of methotrexate and sulphasalazine.
Rheumatology International  •  2006  |  View Paper
At 1 microM, MTX induced differentiation was associated with a marked reduction in the intracellular concentrations of adenosine and, consequently, S-adenosylmethionine (SAM), S-adenosylhomocysteine, polyamines and glutathione (GSH).
Journal of cellular biochemistry  •  2006  |  View Paper
BACKGROUND Animal studies suggest that the anti-inflammatory effect of methotrexate (MTX) is mediated by increased adenosine concentrations.
CONCLUSIONS MTX treatment inhibits deamination of adenosine and potentiates adenosine-induced vasodilatation.
MTX … adenosine (0.5 and 1.5 microg/min/dl of forearm tissue; mean (SE) FBF ratio increased from 1.2 (0.2) to 1.4 (… 1.3 (0.1) to 1.8 (0.2) and 3.2 (0.5) ml/dl/min during MTX treatment; p<0.05).
These effects on the adenosine kinetics in humans may contribute to the therapeutic efficacy of MTX.
Annals of the rheumatic diseases  •  2006  |  View Paper
Recent evidence suggests that methotrexate exhibits its antiinflammatory effects through adenosine.
Clinical and experimental dermatology  •  2005  |  View Paper
Our data confirms that adenosine , and its stable analog 5'-N-ethylcarboxamideadenosine, can mimic the differential effects of MTX on NURR1 transcription.
The Journal of Immunology  •  2005  |  View Paper
Thus, the suppression of T cell activation and T cell adhesion molecule expression, rather than apoptosis, mediated in part by adenosine or polyglutamated MTX or both, are important mechanisms in the anti-inflammatory action of MTX.
Clinical immunology  •  2005  |  View Paper
Moreover, MTX interferes with the metabolic pathways of folates, excitatory amino acids, homocysteine, S-adenosylmethionine/S-adenosylhomocysteine, adenosine and biopterins, inducing biochemical alterations which have been associated with neurotoxic symptoms.
Chemotherapy  •  2003  |  View Paper
Methotrexate also blocks DNA synthesis and hence cellular proliferation but also induces release of adenosine.
Clinical and experimental dermatology  •  2002  |  View Paper
Show More