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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Metformin inhibits mitochondrial respiratory chain complex I which leads to change in adenosine mono-phosphate ( AMP) to adenosine tri-phosphate (ATP) ratio.”
Metformin as a Treatment Strategy for Sjögren’s Syndrome“This study shows that metformin suppressed CD133 expression mainly by affecting the CD133 P1 promoter via adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling but not the mammalian target of rapamycin (mTOR).”
“Treatment with metformin promoted the phosphorylation of the catalytic &agr; subunit of adenosine 5′‐monophosphate‐activated protein kinase (AMPK&agr;), co‐administration of AMPK inhibitor suppressed the stimulatory effects of metformin on AMPK&agr; phosphorylation.”
“Our findings showed that activation of AMPK by metformin (300 mg/kg) significantly increased the MNCV and reduced the levels of inflammatory cytokines.”
Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy“CONCLUSION Me formin in vivo and ex vivo increases ADO si gnaling in CC, most probably interfering with NO formation and ADO breakdown.”
“Ex vivo metformin time and dose dependently increased the relaxant effect of ADO in RD.”
“In vivo metformin treatment in both RD and HFD significantly increased the ADO relaxing effect (P < 0.0001 and P < 0.01, respectively, vs. relative untreated groups) although to a different extent.”
“Experimental studies have shown that metformin can increase the intracellular concentration of adenosine monophosphate , which is a major determinant of the intracellular formation of adenosine.”
“However, it is known that metformin stimulates catabolic pathways through the activation of adenosine monophosphate –activated protein kinase (AMPK) [2] and that a synthetic activator of AMPK, 5-aminoimidazole4-carboxamide ribofuranoside (AICAR) inhibits adipogenesis in the pre-adipocyte cell line, 3T3-L1 [3].”
“Furthermore, metformin treatment for 1 h simultaneously increased the Thr172 phosphorylation of PRKAA ( adenosine 5′ monophosphate-activated protein kinase alpha) and the Ser79 phosphorylation of ACACA (acetyl-Coenzyme A carboxylase alpha).”
“In addition, metformin significantly increased AMPK activation in CPZ mice.”
“ Metformin , a glucose-lowering drug, attenuates inflammatory responses by activating adenosine monophosphate protein kinase (AMPK) which suppresses nuclear factor kappa B (NF-κB).”
Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis.“Furthermore, metformin induced adenosine 5′‐monophosphate‐activated protein kinase (AMPK) activation.”
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