Possible Interaction: Adenosine and Magnesium Cation

“… magnesium ions … adenosine increases the magnesium content considerably, thus approaching the magnesium level of calf erythrocytes.6.The hemoglobin retention of adult cattle erythrocytes incubated with … to that of untreated calf erythrocytes indicating that the cellular magnesium level is essential for the extent of release of hemoglobin by hemolysis.”

“ Magnesium ion is an allosteric effector of 5'-nucleotidase and thus activates adenosine production from AMP.”

“Although [3H]norepinephrine release from rat cortical slices evoked by 500 microM NMDA was abolished by 1.2 mM Mg++, which produces a voltage-sensitive, uncompetitive block of NMDA-channels, adenosine release was increased in the presence of Mg++.”

“A possible mechanism of inhibitory action of adenosine on the synaptic transmission and the role of Ca++ and Mg++ ions in this process are discussed.”

“Elevation of external magnesium concentration increased inhibitory effect of adenosine while its reduction diminished it.”

“The presence of magnesium ions and taurine has also been shown to result in a threeto fourfold increase in the rate of synthesis of CAMP by the ameba .”

“Ostern & Mann (… that Mg++ inhibits the deamination of … triphosphate and of muscle adenylic acid by frog muscle extract whilst, usingmanmalian tissue extracts, Conway & Cooke (1939), working with adenosine and muscle adenylic acid, … Brady (1942), working with adenosine, found Mg++ to be without effect on the deamination of these compounds.”