Possible Interaction: Adenosine and Lidocaine

“When added to high-potassium cardioplegia, it was found safe, but with no obvious clinical benefit.4-…-operative atrial fibrillation in one of the trials.9 Laboratory investigation has found that the combination of lidocaine … adenosine is more protective than either alone, with … been used clinically in hyperkalaemic mixtures.”

“The combination of adenosine and lidocaine (AL, adenocaine) has been shown to (1) inhibit neutrophil inflammatory activation and (2) improve left ventricular function after ischaemia.”

“RESULTS … nosine an d … ocaine al one inhibited O(2)(-) production in a dose-dependent manner (adenosine reduced to 67% ± 8.4% and 21% ± 2.2% of maximal stimulation at ….1 and 10 μmol/L, respectively, lidocaine reduced to 57.9% ± 18.6% and 28% ± 5% at 10 and 100 μmol/L, respectively).”

“On the contrary, it has been reported that cardioprotection may not be achieved with adenosine alone but may occur if adenosine is co-administered with lidocaine.”

“A high concentration of lidocaine , 50 and 500 microM was associated with a reduced release of endogenously produced adenosine.”

“A low concentration of lidocaine , 0.05 microM, increased the uptake of exogenously administered adenosine.”

“We examined whether pretreatment with lidocaine could influence the cardiac kinetics of adenosine and thereby strengthen the physiologic responses of the nucleoside, either exogenously administered or endogenously produced.”

“given immediately before coronary artery occlusion and just before reperfusion), or 4) adenosine plus lidocaine , n = 11.”