supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Adenosine
drug:
Leukotriene B4
Research Papers that Mention the Interaction
“ Adenosine , an endogenous autacoid with several anti-inflammatory properties, blocks the synthesis of leukotriene B4 while it potentiates the cyclooxygenase-2 pathway in fMLP-treated neutrophils, following activation of the A2A receptor.”
Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal“These results demonstrate that endogenous Ado efficiently downregulates ligand-stimulated LTB4 biosynthesis in PMN suspensions, pointing out a potentially important regulatory function of Ado in inflammatory exudates.”
“ 2‐Cl‐adenosine also inhibited the synthesis of LTB4 induced by FMLP in these isolated LPS and TNF‐α‐treated cells; however, 2‐Cl‐adenosine was a more potent inhibitor of LTB4 synthesis in neutrophils than monocytes.”
“6 The present data demonstrate that adenosine , acting through A2 receptors, exerts a potent inhibitory effect on the synthesis of LTB4 and thus contribute to the understanding of its anti‐inflammatory properties.”
“In context with previous studies, these results suggest that endogenous ADO exerts a tonic inhibitory influence on granulocytes during LTB4 stimulation and this action can be unmasked with methylxanthines.”
Potentiation of leukotriene B4-mediated inflammatory response by the adenosine antagonist, 8-phenyl theophylline.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback