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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The further addition of 25 to 100 µM adenosine inhibited the uptake of radiolabeled thymidine and leucine into acid precipitable material, and also increased intracellular levels of S -adenosylhomocysteine (AdoHcy) from 3- to 8-fold.”
Inhibition of methylation by adenosine in adenosine deaminase-inhibited, phytohemagglutinin-stimulated human lymphocytes.“ Leucine treatment … adenosine monophosphate/ATP ratio in myoblasts by 36.4 +/- 9.1% (P < 0.05) and reduced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) … at Thr172 (28.6 +/- 4.9% reduction, P < 0.05) and inhibited AMPK activity (43.6 +/- 3.5% reduction, P < 0.05).”
Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase.“ Adenosine activates adenosine-induced inwardly rectifying K+ current (IKAdo) and inhibits isoproterenol (100 nM)-stimulated L-type Ca2+ current (beta-ICa, L ) of guinea pig atrial myocytes with EC50 values of 2.17 and 0.20 microM, respectively.”
“ Adenosine decreased ICa, L and activated IK,ADO of AV nodal cells.”
“In atrial myocytes adenosine has a small inhibitory effect on basal L‐type calcium current (ICa, L ), but no effect on T‐type calcium current (ICa,T).”
“This indirect cAMP‐dependent mechanism of action has been shown to be responsible for the inhibition by adenosine of isoproterenol‐stimulated ICa, L , delayed rectifier K+ current (IK), chloride current (ICl), the transient inward current ITi, and the pacemaker current IF.”
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