“ INH also inhibited both the oxidized nicotinamide adenine dinucleotide (NAD+) and adenosine 5′-monophosphate stimulation of reduced NAD (NADH) oxidase activity associated with the M. phlei and M. tuberculosis H37Ra electron transport particles.”
“Therefore, INH inhibition of regulation and/or stabilization of the electron transport pathway by NAD+ or adenosine 5′-monophosphate may account, in part, for the lethal action of the drug on mycobacteria.”