Possible Interaction: Adenosine and Isoflurane

“ ADO could reduce isoflurane requirements during joint‐associated surgery, as an indication of antinociception in deep somatic pain.”

“ Isoflurane induced new CD73 synthesis and increased adenosine generation in cultured kidney proximal tubule cells and in mouse kidney.”

“Conclusions: In vivo APC by isoflurane decreases sensitivity of the sarcolemmal KATP channel to inhibition by adenosine 5′-triphosphate and decreases adenosine 5′-diphosphate sensitivity.”

“Although adenosine and S-nitroso-N-acetyl-penicillamine each alone did … flavoprotein fluorescence, nor did they confer significant cardioprotection, coadministration of adenosine and S-nitroso-…-acetyl-penicillamine with isoflurane conferred a highly significant reduction of infarct size and improvement … left ventricular function without increasing flavoprotein oxidation over isoflurane alone.”

“The coronary reserve (mean +/- SD) measured by PET was slightly lower with the combination of isoflurane and adenosine (1.4 +/- 0.5) than with propofol and adenosine (2.1 +/- 0.5).”

“Blockade of adenosine receptors or phosphatidylinositol kinases abolishes the sensitization effect, suggesting that the adenosine and phospholipid signaling pathways may be involved in the actions by isoflurane.”

“Background: This investigation tested the hypothesis that adenosine (A1) receptor blockade modulates the cardioprotective effects of isoflurane.”