Possible Interaction: Adenosine and Interferons

“The ratio of diadenosine 5′,5‴‐P1,P3‐triphosphate to diadenosine 5′,5‴‐P1,P4‐tetraphosphate (Ap3A/Ap4A) is sensitive to the cellular status and alters when cultured cells undergo differentiation or are treated with interferons.”

“ ADO inhibited mononuclear cell proliferation and interferon-γ production in humans.”

“Cell treatment with levamisole (200 micrograms/ml), methisoprinol (1 mg/ml), or adenine or adenosine (33 or 100 micrograms/ml, respectively) potentiated the anti-encephalomyocarditis virus activity of human interferon by 8- to 32-fold.”

“Preliminary studies in humans have revealed that treatment with interferon-α (IFN-α), which upregulates platelet tetherin/BST-2 expression, also reduces adenosine diphosphate-stimulated platelet receptor function and reactivity.”

“The stimulation of (pro)insulin biosynthesis by adenosine , D-glyceraldehyde, mannose, N-acetylglucosamine and leucine was also inhibited by interferon , with no effect on insulin release.”

“Likewise, late interferon production is reduced much stronger than early interferon production by a combination of adenosine , L-homocysteine thiolactone, and erythro-9[3-(2-hydroxynonyl)]-adenine (EHNA) inducing in cells an accumulation of S-adenosylhomocysteine which inhibits SAM mediated methylation reactions.”

“Thus, treatment of cells with various derivatives of adenosine 3 ' 3 cyclic monophosphate CAMP),'^-'' or compounds that increase the intracellular levels of CAMP:' has been shown to potentiate the antiviral action of interferon.”

“Summary When cells were … with amounts of interferon which caused a 92 to 99% reduction in virus production, the yields of infectious RNA were inhibited by 67 to 81%, while the rate of incorporation of [3H]adenosine into total virus specific RNA was inhibited by only 48 to 65%.”