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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Adenosine
drug:
Interferon-Alpha
Research Papers that Mention the Interaction
“Previous studies demonstrated that adenosine can suppress IFN‐γ production by iNKT cells.”
The A2aR adenosine receptor controls cytokine production in iNKT cells“We hypothesized that adenosine achieves these protective effects by interrupting IFN-γ signaling in activated macrophages.”
“However, when PBMC were stimulated with IFN‐α, adenosine did not decrease, but synergistically increased, the IFN‐γ production of NK cells.”
“Upregulation of ecto‐5′‐nucleotidase and a subsequent increase in adenosine production might contribute to the beneficial effects of IFN‐β on MS via enhancing the endothelial barrier function.”
“In contrast, 2′-O-methyl groups at adenosine and uridine residues reduced both IFN-α secretion and gene-silencing activity.”
“Thus, we propose a novel mechanism whereby IFN-γ contributes to host defense by desensitizing macrophages to the immunoregulatory effects of adenosine.”
IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response“Treatment of stimulated CD4(+) T-cells with adenosine (25 μM) potently reduced IFN-γ release which is mediated by adenosine A2a receptors (A2aR).”
“Treatments that inhibit macrophage proliferation by blocking the cell cycle at the G1 phase, such as adenosine , forskolin, or LPS, blocked the IFN-γ induction of IA.”
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