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“Upregulation of ecto‐5′‐nucleotidase and a subsequent increase in adenosine production might contribute to the beneficial effects of IFN‐β on MS via enhancing the endothelial barrier function.”
“Thus, we propose a novel mechanism whereby IFN-γ contributes to host defense by desensitizing macrophages to the immunoregulatory effects of adenosine.”
American journal of physiology. Cell physiology • 2011 | View Paper
“Treatments that inhibit macrophage proliferation by blocking the cell cycle at the G1 phase, such as adenosine , forskolin, or LPS, blocked the IFN-γ induction of IA.”