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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“During adenosine infusion, insulin enhanced MBF by 20% (P = 0.018) in ischemic regions and 18% (P = 0.045) in nonischemic regions.”
Insulin improves myocardial blood flow in patients with type 2 diabetes and coronary artery disease.“ Insulin increased significantly adenosine stimulated flow by 23% in diabetic and 17% in non-diabetic subjects (NS between the groups).”
“It has been demonstrated that adenosine , through activation of P1 receptors present on adipocytes and pancreatic islets cells, inhibits the release of insulin.”
“Local hormones such as adenosine or prostaglandins can dramatically change the sensitivity of glucose transport in muscle to insulin.”
“As we have observed previously with glucagon and catecholamines, inhibition of insulin action by VIP was observed only when accumulation of adenosine in the incubation medium was prevented by addition of adenosine deaminase.”
“Incubation of human and rat hepatoma cells with insulin (1 mU/10(6) cells) decreases their content of adenosine 3':5'-monophosphate by more than half after 1 h and by about a quarter after 4 h. 2.”
“Accumulating evidence highlights a critical role for the adenosine system in the regulation of insulin and glucose homeostasis and the pathophysiology of type 2 diabetes (T2D).”
“Removal of adenosine brought about a small but significant increase in the concentration of insulin required for half-maximal stimulation of glucose transport.”
“ Insulin induced the release of adenosine trisphosphate (ATP), adenosine , and serotonin from platelet-dense granules in a NO-dependent manner.”
“Thus, insulin elicits the release of vasoactive concentrations of ATP and adenosine from human platelets via a NO–G kinase–dependent signaling cascade.”
“In addition, this insulin resistance involves an impairment of the system by which adenosine acts to modulate insulin signal transduction.”
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