Possible Interaction: Adenosine and Inosine

“Selective substitution of inosine for adenosine in pre-mRNA transcripts can alter splicing, mRNA stability, and the amino acid sequence of the encoded protein.”

“Here, it is shown that adenosine both binds to Schistosoma mansoni PNP and behaves as a weak micromolar inhibitor of inosine phosphorolysis.”

“In particular, adenosine and deoxyadenosine, the ADA substrates, increased markedly while the product inosine decreased.”

“Site-specific deamination of an adenosine to an inosine converts the glutamine codon to that of arginine.”

“ Inosine , guanosine, 2'-deoxyadenosine, tubercidin, formycin B, and the pyrimidines uridine, thymidine, and cytidine (all 100 microM) inhibited transport of adenosine and inosine about 50-100%, while 3'-deoxyinosine showed weak inhibitory action.”

“RNA editing of adenosines to inosines contributes to a wide range of biological processes by regulating gene expression post-transcriptionally.”

“Application of adenosine (1mM) resulted in a time-dependent increase in intracellular adenosine, inosine , AMP, ATP, AdoHcy and AdoMet concentration.”

“catalyzes the irreversible hydrolytic deamination of adenosine to produce inosine and ammonia.”

“Saturation of such removal mechanisms when higher concentrations of adenosine are released results in the accumulation of inosine , explaining the strong purine signal during high-rate activity.”

“Thus, during cardiogenesis, disturbances of nucleosides metabolism and transport, can lead to interstitial accumulation of ADO and INO and provoke arrhythmias in an autocrine/paracrine manner through A1AR and A2AAR stimulation and ERK2 activation.”