Possible Interaction: Adenosine and Indomethacin

“ Indomethacin pretreatment decreased adenosine hyperresponsiveness and shifted the dose-response curves of adenosine challenge to the right with a geometric mean PD20 of 1.28 mg (95% confidence limits, 0.64 to 2.56).”

“In anaesthetised rats, the PG synthesis inhibitors diclofenac or indomethacin reduced muscle vasodilatation evoked by systemic hypoxia or adenosine , but not that evoked by iloprost, a stable analogue of prostacyclin (PGI2), or by an NO donor.”

“The biphasic response to adenosine was markedly depressed by 10 microg/ml indomethacin and was augmented by combining this agent with quinidine.”

“ Adenosine release (HPLC) into the coronary effluent after ischemia was significantly enhanced in the presence of indomethacin.”

“In addition, the dose-response curve for adenosine was displaced downward and to the right by indomethacin , indicating also the involvement of prostaglandins.”

“ Indomethacin decreased glucose release stimulation by adenosine in both anterograde and retrograde perfusion only when DMSO was the vehicle.”

“ Indomethacin reduced relaxations to bradykinin, A23187, and adenosine (p < 0.05), and glibenclamide impaired adenosine responses (p < 0.05).”

“ Adenosine levels in the cortical superfusates were significantly elevated following indomethacin administration.”

“ Indomethacin shifted the concentration-response curves for adenosine and ATP to the right.”

“As with NA, the potentiation by histamine and adenosine is inhibited by indomethacin.”