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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Hypochlorite
Research Papers that Mention the Interaction
“Preexposure of hearts to the oxidant hypochlorous acid HOCl ) prevented dilatations by ACh, BK, MeATP and Ado (0.1 microM), and the response to Ado (5 microM) was reduced by 68%; postischemic hyperemia was attenuated.”
Different endothelial mechanisms involved in coronary responses to known vasodilators.“ Adenosine and its nucleotides react with hypochlorite to form unstable products that have been identified as the N6 chloramine derivatives.”
“We show that reaction of HOCl with the exocyclic -NH(2) groups of cytidine, adenosine , and guanosine, and the ring NH groups of all bases, yields chloramines (RNHCl/RR'NCl).”
Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals.
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