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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Hydrogen Peroxide
Research Papers that Mention the Interaction
“The peak current of H2O2 decreased with increase in the concentration of adenosine over a range of 1-750 nM with detection limit 1 nM. In addition the proposed aptasensor showed excellent selectivity toward adenosine in compared to some other nucleosides such as guanosine, cytidine and uridine.”
Highly selective and sensitive adenosine aptasensor based on platinum nanoparticles as catalytical label for amplified detection of biorecognition events through H2O2 reduction.“Increasing concentrations of adenosine dose-dependently reduced this tissue-toxic H2O2 production in both groups with a half-maximal inhibitory concentration of 25 nmol/L and 114 nmol/L in HV and SS patients, respectively.”
“ Adenosine also significantly enhanced IL-10 production after hydrogen peroxide and LPS stimulation and dose-dependently inhibited TNF secretion.”
“In most experiments, 4.7 x 10(-7) M and 2.5 x 10(-8) M adenosine caused 50% suppression of H2O2 release in response to TNF-alpha and FMLP, respectively, and 10 microM caused 100% suppression.”
“This H2O2 induced aggregation of normal platelets can be inhibited by adenosine , suggesting a possible mechanism that H2O2 might stimulate platelets to release ADP, which in turn causes platelet aggregation.”
“The inhibitory effect of H2O2 can be prevented and largely reversed by plasma, glucose, adenosine , and inosine.”
“ H2O2 production was markedly increased by adenosine in EX LCX arterioles.”
Exercise Training Restores Coronary Arteriolar Dilation to NOS Activation Distal to Coronary Artery Occlusion: Role of Hydrogen Peroxide“Intraluminal incubation of vessels with H2O2 (100 &mgr;mol/L, 60 minutes) did not alter basal tone but inhibited vasodilations to adenosine and ionomycin in a manner similar as that by NO synthase inhibitor L-NAME.”
“It is concluded that the ability of H2O2 to oppose hypoxic depression does not occur at the level of the adenosine receptor since added adenosine was still effective in inhibiting the evoked potential in the presence of H2O2.”
“After exposure to 250 microM hydrogen peroxide , the intracellular levels of adenosine , adenosine diphosphate, and adenosine triphosphate all initially increased in the first 1 to 15 minutes, but subsequently decreased significantly, ultimately reaching close to 40% below control levels.”
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