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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Hydrocortisone
Research Papers that Mention the Interaction
“ Hydrocortisone potentiates the effect of adenosine on disaggregation: in the absence of the hormone IC50 for adenosine is 2.5 µM, while in the presence of 3 and 10 µM hydrocortisone it drops to 1.7 and 0.4 µM, respectively.”
Early stages in the mechanism of action of glucocorticoids on human platelets. Effect of hydrocortisone on platelet aggregation“In addition to increasing lymphocyte cAMP levels, hydrocortisone (10(-6)-10(-3)M) markedly potentiated the effect of many adenylate cyclase-stimulating agents including beta adrenergic stimuli, histamine, adenosine , prostaglandin E1 and cholera enterotoxin.”
“Recent data show that adenosine appears to inhibit baseline levels of fetal cortisol and to restrict the increase in ACTH and cortisol during moderate hypoxia.”
Adenosine A(1) receptor mediated suppression of adrenal activity in near-term fetal sheep.“The simultaneous administration of cortisol and adenosine (both at 10(-4) mol l(-1)) induced a significant reduction (p<0.001) of the coronary tree response elicited by each drug alone.”
“It has been reported that adenosine inhibits the liver glycogen accumulation induced by cortisol in adrenalectomized rats [l] .”
Adenosine, a glucogenic and lipogenic compound
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