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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
supplement:
Homocysteine
Research Papers that Mention the Interaction
“We found that Hcy (50 micromol/L) significantly decreased cell numbers, viability, and induced a G1/S arrest in HUVEC in the presence of adenosine (Ade, 50 micromol/L).”
“Cordycepin inhibited 29-O methylation of nuclear RNA to a greater extent than base methylation, while the combination of adenosine and homocysteine inhibited these sites to equal degrees.”
“Upon the addition of homocysteine, adenosine produced 65% inhibition of methylation of nuclear RNA, whereas 29-deoxyadenosine was ineffective and the inhibitory effect of cordycepin was not potentiated.”
“ Adenosine alone did not induce cell death, assessed by LDH release, both in HA and GBM cells, but potentiated cytotoxic effect of homocysteine in HA and in U87MG and U373MG cells.”
“The effect of adenosine on HA proliferation/viability was potentiated by 100µM-homocysteine.”
Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines“On the other hand, adenosine significantly inhibits the hydrolysis reaction and prevent the formation of homocysteine.”
“ Adenosine induced a time- and dose-dependent increase in HCys in cell culture.”
“ Homocysteine induces a stereospecific, time‐ and dose‐dependent cell adhesion which is prevented by adenosine.”
“In the combined Alzheimer and control groups a significant negative correlation was found between the plasma concentrations of homocysteine and adenosine (r = -0.769, p < 0.0001).”
“A significant decrease of intracellular glutathione concentration was noted both in the presence of homocysteine (250 micromol/l) alone and in the presence of the combination of homocysteine and adenosine (250 micromol/l).”
“A significant growth retardation was observed in HeLa cell cultures in the combined presence of homocysteine and adenosine , but first at concentrations of 250 micromol/l of each.”
“The differentiation induced by adenosine dialdehyde was prevented by homocysteine and that by nitrous oxide was inversely related to the medium methionine concentration.”
“The addition of adenosine up to 50 mumol/L decreased the growth of B lymphoblasts, and these changes were enhanced by the addition of 100 mumol/L homocysteine thiolactone.”
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