Possible Interaction: Adenosine and Halothane

“Aggregation induced by halothane could be inhibited by EGTA, PGE1, adenosine and verapamil, but not by aspirin.”

“A … by halothane … adenosine diphosphate-induced platelet aggregation was measured for human platelets in plasma anticoagulated with sodium citrate 6.8 mmol litre-1 or 13.6 …-1, or heparin 2 u. ml-1 and for platelets separated from plasma by albumin density gradient centrifugation and requiring no anticoagulant.”

“The previously observed adenosine antagonism of halothane activation of sarcoplasmic reticulum Ca2+ release was due to competition between adenosine and ATP, rather than between halothane and ATP.”

“During halothane anesthesia, adenosine infusion increased portal tributary (90%, P < 0.01) and hepatic arterial (37%, P < 0.05) blood flows, thereby increasing total liver blood flow to values similar to those in awake adenosine infused rats.”

“During early hypoperfusion (10 min) at 25% PP, 1.65% halothane significantly reduced release of ADE , INO, and LAC.”

“During late hypoperfusion (40 min) the differences in LAC release diminished, but release of ADE and INO remained lower in the 1.65% halothane group.”

“The release of INO during reperfusion was reduced by halothane; however, ADE release increased with halothane suggesting less conversion of ADE to INO.”

“Left ventricular blood flow decreased significantly during halothane (-35%) and enflurane (-23%); was unchanged from control during isoflurane (-9%); but significantly increased during adenosine (+397%).”

“ Adenosine significantly reduced halothane MAC, by 49%, from 0.76 +/- 0.05 to 0.39 +/- 0.05 vol% (mean +/- SEM).”

“We conclude that exogenous adenosine substantially reduces halothane MAC in dogs and that this effect is blocked by the concurrent administration of the adenosine-receptor antagonists aminophylline or 8-PT.”