Possible Interaction: Adenosine and Glyburide

“ Glibenclamide also inhibited the carbachol and adenosine induced contractions.”

“However, glibenclamide abrogated the protective effect of adenosine.”

“Intracerebroventricular treatment of mice with …, 25 pg/site), glibenclamide (an ATP-sensitive K(+) channel inhibitor, 0.5 pg/site), charybdotoxin (a large- and intermediate-conductance calcium-activated K(+) channel …-conductance calcium-activated K(+) channel inhibitor, 10 pg/site) was able to potentiate the action of subeffective doses of adenosine (….)”

“When pretreated with glibenclamide (a nonselective ATP-sensitive potassium channel blocker), the inhibitory effects of adenosine and CPCA on blood pressure variability were significantly prevented.”

“ Glibenclamide (0.3 μM) reduced significantly hypoxia-induced vasodilatation (differential change in CPP of −27±6%) as well as the dilator response to 10 μM adenosine and to the stable PGI2-analogue, iloprost.”

“ Glibenclamide (10 nmol), a selective K(ATP) channels antagonist, suppressed the increase of ONH blood flow induced by 10 nmol adenosine significantly (P<0.001, ANOVA).”

“Further, vasodilator responses to neither adenosine nor ATP were sensitive to inhibition by the potassium channel blocker glibenclamide , in isolated mesenteric perfused bed.”

“Inhibition of the Na-K pump with ouabain or with low K + medium, as well as inhibition of the K ATP channels with glibenclamide , both diminished the adenosine induced vasodilation (P = 0.003, P = 0.01, and P = 0.003, respectively).”

“The A2A adenosine receptor‐mediated inhibitory responses to NECA were reduced by the KATP channel blocker, glibenclamide (3 μM) and abolished by charybdotoxin (100 nM).”

“N-LA, L-NAME and glibenclamide attenuated the effects of adenosine at doses of < 2.5 μM/ kg/min and pinacidil potentiated its effects.”