Possible Interaction: Adenosine and Glucose

“In palmitic acid (PA)-induced HepG2 cells, VA decreased glucose production and the expression of PEPCK and G6Pase proteins, also activated AMPK pathway.”

“In the perfused guinea-pig liver glucose synthesis with lactate, propionate, glycerol and fructose was also inhibited by Ado ; however, when precursors such as pyruvate, glutamine and a mixture of lactate + pyruvate were supplied to the liver Ado did not inhibit gluconeogenesis.”

“We further showed that lamellocytes precursors released adenosine that suppressed the consumption of glucose by non-immune tissues and thus slowed down the host development.”

“ Adenosine stimulates hepatic glucose production in vitro.”

“A net synthesis of ATP also occurs with adenosine concentration below 1.5 microM, if supplemented with glucose.”

“High concentrations of adenosine reverse the inhibition by glucose and enhance agglutination in the presence of maltose and cellobiose.”

“Gabrio et al.1–3 have shown that addition of adenosine or inosine re-establishes the cell content of organic phosphate, increases the consumption of glucose , and thus the post-transfusion viability.”

“Real-time detection by in situ purine biosensors further revealed that the adenosine level doubles in response to glucose , and triples during the wakefulness period.”

“ CADO treatment decreased the plasma glucose concentration and glucose and protein excretion by more than 30% in both strains.”

“It is also well established that suppression of adenosine action increases insulin-secretory response of β-cells to glucose.”