Possible Interaction: Adenosine and Gamma-Aminobutyric Acid

“In the central nervous system (CNS), adenosine plays an important role in regulating neuronal activity and modulates signaling by other neurotransmitters, including GABA , glutamate, and dopamine.”

“The influence of adenosine acting on the A2A receptor in the striatum and GP would therefore be to increase GABA release from striatopallidal neurones, and thus presumably inhibit pallidal output neurones including those to the subthalamic nucleus.”

“In conclusion, the results showed that adenosine inhibits synaptic GABA release via presynaptic A₁ receptors in the PVN-RVLM neurons, indicating a potential of adenosine A₁ receptors in regulating sympathetic tone in normal and disease states.”

“Adenosine (100 μM) reversibly decreased mIPSC frequency without affecting the current amplitude, indicating that adenosine acts presynaptically to decrease the probability of spontaneous GABA release.”

“Because A(1)R blockade did not affect the median miniature IPSC amplitude, our results demonstrate that adenosine reduces gamma-aminiobutyric acid (GABA) release probability via presynaptic A(1)Rs at P5-7.”

“Here, we report that GABA release from fast-spiking (FS) cells, the most prevalent interneuron subtype in neocortex, is robustly inhibited following activation of muscarinic, serotonin, adenosine , and GABA(B) receptors--an effect that regulates FS cell control of excitatory neuron firing.”

“In this study the adenosine A2A receptor agonist CGS21680 was used to evaluate adenosine receptor specificity and the interrelation of adenosine and GABA in the inhibition of inspiratory drive.”

“The present results indicate that the suppression of adenosine on IGABA is mediated by adenosine A1 receptor and through a Ca2+-independent protein kinase C transduction pathway, and that the interactions between adenosine and GABA might participate in the modulation of nociceptive information transmission at the SDCN.”

“The results indicate that: (1) the suppression of adenosine on I(GABA) is mediated by adenosine A(…) receptor and through a Ca(2+)-independent protein kinase C transduction pathway; (2) the interactions between adenosine … GABA might be involved in the modulation of nociceptive information transmission at spinal cord level.”

“These results suggest that adenosine inhibits synaptic release of GABA and glutamate by stimulation of presynaptic A(1) receptors in the subthalamic nucleus.”