Possible Interaction: Adenosine and Gaba Agents

“In situ, adenosine has been shown to inhibit some of the glutamatergic and GABAergic synaptic inputs to granule cells.”

“A presynaptic origin was suggested as following: adenosine increased paired-pulse ratio as well as reduced GABAergic miniature IPSC frequency without affecting the miniature IPSC amplitude.”

“Our experiments indicate that ATP and adenosine substantially reduce the bicuculline- and gabazine-sensitive GABAergic input to granule cells.”

“Recent physiological studies indicate that GABAergic mechanisms may be involved in this inhibitory action of adenosine , via their A(2A) receptors.”

“Similarly, adenosine exerted a strong inhibitory action on spontaneous glutamatergic synaptic events recorded from GABAergic interneurons and on interictal bursts that developed in CA3 principal cells after blockade of gamma-aminobutyric acid type A (GABA(A)) receptors with bicuculline.”

“ Adenosine reduced the frequency of GABAergic and glycinergic spontaneous IPSCs without changing their amplitude.”

“ Adenosine reversibly reduced the amplitude of GABAergic and glycinergic electrically evoked IPSCs (eIPSCs) in a dose-dependent manner (EC50 = 14.5 and 19.1 microM, respectively).”

“In paired-pulse experiments, the ratio of the second to first GABAergic or glycinergic eIPSC amplitude was increased by adenosine , whereas the response of SG neurons to exogenous GABA or glycine was unaffected.”

“In immature neurons, adenosine (10 microM) reversibly decreased GABAergic mIPSC frequency without affecting the mean current amplitude.”

“ Adenosine had no effect on the frequency of spontaneous inhibitory postsynaptic currents in cholinergic neurons or GABAergic neurons with large H-currents but reduced them in a group of GABAergic neurons with smaller H-currents.”