Possible Interaction: Adenosine and Fluorouracil

“Although adenosine had little cytotoxic activity, the addition of adenosine significantly potentiated the in vitro cytotoxicity of 5-FU.”

“Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate , together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil.”

“Abstract Inosine, adenosine and guanosine, through the reaction catalyzed by purine nucleoside phosphorylase, stimulated the uptake of 5-FU and the conversion of 5-FU to F-uridine nucleotides in a FU-resistant cell line.”