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Last Updated: 2 years ago

Possible Interaction: Adenosine and Fluorides

supplement:

Adenosine

supplement:

Fluorides

Research Papers that Mention the Interaction

The Km value calculated for diadenosine tetraphosphate in the presence of Mg2+ is 10 microM … in the presence of Zn2+ 40 microM. Adenosine 5'-tetraphosphate, guanosine 5'-tetraphosphate, and fluoride proved to be inhibitors of the diadenosine tetraphosphate hydrolase; the I50 values were 6, 10, and 20 microM, respectively.
Protein expression and purification  •  1993  |  View Paper
Fluoride potently inhibits diadenosine tetraphosphate hydrolysis in the presence of Mg(2+) (IC(50)=20microM), whereas it is ineffective in the presence of Zn(2+), supporting the view that inhibition involves a specific, MgF(3)(-)-containing transition state analogue complex.
The international journal of biochemistry & cell biology  •  2007  |  View Paper
After incubation with adenosine and F- ions a distinct decrease of cAMP level was observed in N fractions from the midbrain and thalamus with hypothalamus and in mitochondrial fractions obtained from all the investigated regions.
Acta physiologica Polonica  •  1984  |  View Paper
10(-5) M) adenosine inhibits the activation by fluoride practically completely, while at increasing ATP concentrations the inhibition of the fluoride-stimulated activity of adenylate cyclase is decreased.
Biokhimiia  •  1982  |  View Paper
Adenosine inhibited basal and fluoride- or hormone-stimulated adenyl cyclase activities from various sources.
Canadian journal of physiology and pharmacology  •  1973  |  View Paper