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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Adenosine is an important neuromodulator, that has been indicated to be affected by acute and chronic exposure to ethanol.”
Inhibition of ecto-5′-nucleotidase and adenosine deaminase is able to reverse long-term behavioural effects of early ethanol exposure in zebrafish (Danio rerio)“Microdialysis data indicated that acute ethanol significantly increased AD release in the LHA but had no effect on orexin A levels.”
“ Alcohol , via its action on AD uptake, increases extracellular AD resulting in the inhibition of BF wake-promoting neurons.”
“ Adenosine seems to interact with other neurotransmitter systems and with some substances like alcohol , which elevate the basal levels of adenosine.”
“ Ethanol interacts directly with the adenosine system by blocking nucleoside transporters in the cell membrane.”
“New research suggests that ethanol interacts synergistically with adenosine and dopamine signaling to amplify the effect of drinking.”
“Through this mechanism, adenosine may mediate some of alcohol’s effects, such as intoxication, motor incoordination, and sedation.”
“A schematic summary of our findings is: Etoh-->decreases Ado uptake-->increases Extracellular Ado-->Activation of Adenosine A2 receptor-->increases cAMP-->increases PKA-->-->-->Heterologous Desensitization (decreases cAMP)-->-->-->insensitivity of adenosine uptake to ETOH ”
“Several laboratories have demonstrated the importance of adenosine in mediating the acute and chronic effects of ethanol at multiple levels of investigation in the nervous system.”
“ Ethanol produces a 400% increase in arterial adenosine.”
“In conclusion, adenosine appears to play an important role in the mechanism by which ethanol increases portal blood flow.”
“The ability of adenosine to modify the CNS effects of acute and chronic ethanol was studied by using theophylline, an adenosine antagonist, and dipyridamole, a blocker of adenosine reuptake.”
“The marked changes in adenosine binding characteristics as … as the modification of some CNS effects of ethanol by drugs which influence either adenosine binding to its receptor or the availability of adenosine suggests that adenosine may be involved in the expression of some of the CNS effects of ethanol.”
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