Possible Interaction: Adenosine and Epinephrine

“RESULTS Ad enaline in creased cyclic AMP le vels about two-fold in omental adipocytes but had almost no effect in subcutaneous fat cells.”

“ Adenosine and epinephrine combined had an additive effect on PMN superoxide production and adhesion to EC.”

“ Epinephrine's ability to modulate PMN activation and the potentiating effect of adenosine may constitute a form of physiologic protection against tissue injury in inflammatory and ischemic processes.”

“We report here that adenosine , which is actively released in ischemic conditions, potentiates the effect of epinephrine and reduces the minimal active concentration required to inhibit PMN activation by at least two orders of magnitude.”

“Therefore, adenosine potentiates the in vitro inhibitory effects of calcium channel antagonists on platelet aggregation induced by thromboxane A2 or thromboxane A2 plus epinephrine.”

“Arterial concentrations of noradrenaline and adrenaline increased by 62 and 43%, respectively, during infusion of adenosine.”

“Abstract The inhibitory action … release inducible by epinephrine , comprising several non-steroidal anti-inflammatory drugs (NSAA)—… non-anti-inflammatory agents (NAA)—prostaglandin E 1 , adenosine , dipyridamole, methysergide and cyproheptadine—can be prevented, and under special circumstanees reversed, … of the essential fatty acid, 5,8,11,14 eicosatetraenoic (arachidonic) acid.”

“The plateletaggregating agents ADP and epinephrine , but not vasopressin, markedly inhibited the increase in platelet cyclic [14C]AMP with adenosine.”

“Recent reports show that Epi activates adenosine monophosphate (AMP)–activated protein kinase (AMPK) in adipocytes.”

“This rise in endogenous levels of adenosine then leads to the activation of ocular adenosine receptors and is in part responsible for the ocular hypotensive action of epinephrine.”

“ Ado induced dose-dependent vasodilation in both Epi and Endo arterioles, but vasodilation was greater in Endo arterioles, i.e., increase at 120 s (maximum dilation) after Ado (50 microgram.”

“It was concluded that in the epithelial cells of the rabbit ciliary body, adenosine and epinephrine synergistically potentiate the rise in [Ca2+]i produced by ACh.”