Possible Interaction: Adenosine and Enprofylline

“ Enprofylline , on the other hand, enhanced the response to exogenous adenosine.”

“In addition, caffeine, but not enprofylline , reduced the cardiovascular response to exogenous adenosine.”

“These findings suggest that, with equipotent bronchodilating plasma concentrations, theophylline can inhibit while enprofylline augments some cardio-respiratory stimulant effects of infused adenosine in man.”

“ Enprofylline (E) is a xanthine drug that has poor ability to antagonize physiological actions of adenosine.”

“It is suggested that the lack of tremorogenic effect of enprofylline is related to its lack of CNS-stimulating behavioural effects and, hence, may reflect its low tendency to antagonize neuro-depressant actions of adenosine.”

“Further in vitro studies revealed that the asthmatic response to adenosine is likely to be mediated via the A2B subtype which is selectively antagonised by enprofylline.”

“In the presence of theophylline 110 microM the inhibitory effect of adenosine 4 microM was attenuated, whereas the presence of enprofylline 21 microM enforced the inhibitory effect of adenosine.”

“Furthermore, enprofylline is shown to selectively antagonize the stimulatory response, revealing inhibitory effects of compounds such as 2-chloroadenosine and adenosine.”

“Certain of these cyclic homologues of caffeine, theophylline, theobromine, 3-isobutyl-1-methylxanthine, and enprofylline were inhibitors of binding of adenosine analogues to rat brain A1 and A2 adenosine receptors and were antagonists of A2 adenosine receptors stimulatory to adenylate cyclase in rat PC12 cell membranes.”

“The results show that enprofylline is much more potent as an inhibitor of adenosine A2-receptor-mediated cyclic AMP accumulation than against adenosine A1-receptor-mediated inhibition of field EPSP.”