Possible Interaction: Adenosine and Dopamine

“ Abstract— Adenosine is known to inhibit the release of dopamine from central synaptic terminals.”

“ Adenosine and dopamine interact antagonistically in living mammals.”

“Antagonistic interactions between adenosine and dopamine are (at least partially) caused by allosteric receptor–receptor interactions within A2AR/D2R heteromeric complexes.”

“Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function.”

“It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A2AR-D2R heteromer, by which adenosine decreases the affinity and intrinsic efficacy of dopamine at the D2R.”

“ Adenosine interacts closely with dopamine and plays an important role in the function of striatal GABAergic efferent neurons.”

“…,adenosine has been shown to play an important role not only in the regulation of pathophysiological processes, but also in the modulation of normal physiological … and arousal as well as by impact on pre- or postsynaptic receptors involved in releasing neurotransmitters (e.g. glutamate, acetylcholine, norepinephrine, 5-hydroxytryptamine, dopamine, …).”

“Other neurotransmitters, such as glutamate and adenosine , may also collaborate with dopamine to give rise to the entire picture of schizophrenia.”

“In the central nervous system (CNS), adenosine plays an important role in regulating neuronal activity and modulates signaling by other neurotransmitters, including GABA, glutamate, and dopamine.”

“The action of dopamine is modulated by additional neurotransmitters, including glutamate, serotonin and adenosine.”

“Co-localization of A(2A) and dopaminergic D2 receptors in the striatum creates a milieu for an antagonistic interaction between adenosine and dopamine.”