Possible Interaction: Adenosine and Dobutamine

“In patients off beta-… contracted normally at peak dobutamine increased … with adenosine (0.70 +/- 0.31 to 0.86 +/- 0.46 mL.g-1.min-1; P < .05), whereas those that … did not (0.63 +/- 0.24 to 0.65 +/- 0.19 mL.g-1.min-1; P = NS).”

“Segments of patients on … that contracted normally at peak dobutamine increased … with adenosine (0.78 +/- 0.31 to 1.10 +/- 0.70 mL.g-1.min-1; P < .05), as did … became abnormal (0.74 +/- 0.34 to 1.06 +/- 0.82 mL.g-1.min-1; P = NS).”

“Variable doses of adenosine combined with dobutamine were administered to induce a wide range of MBF.”

“6 The contractile effects of dobutamine could be inhibited almost completely by ACh or adenosine.”

“Both NKH477 (10 mumol/l) and dobutamine (500 nmol/l) increased the tissue adenosine monophosphate level, and decreased the tissue creatine phosphate level (a decrease in energy store) in the heart.”

“Thus adenosine mediates the hyperemia of dobutamine.”

“Dialysate ADO was elevated immediately after insertion of the microdialysis probe, declined rapidly in the first 20 min, stabilized by 60 min, and … and dialysate ADO concentration, ISF ADO concentration within the left ventricular myocardium was estimated to be 0.9-1.3 microM. Dobutamine (10 micrograms.… dialysate ADO (…).”

“The positive chronotropic and inotropic responses to norepinephrine, dobutamine and forskolin were dose-dependently depressed by adenosine.”