Possible Interaction: Adenosine and Dipyridamole

“ Dipyridamole inhibits phosphodiesterase 5 (PDE5) and adenosine re-uptake.”

“The inhibition of platelet adenosine uptake may be related to some of the pharmacological properties of dipyridamole.”

“ Intravenous dipyridamole … adenosine (from 77±25 to 147±50 nmol/L), adenosine-induced increase in FBF (from 4.1±0.8 to 12.6±3 and … of adenosine into the interstitium (to 290±80 and 299±143 nmol/L for the low and high dose, respectively, P =0.04).”

“ Dipyridamole , an inhibitor of cellular uptake of adenosine , may prevent or terminate reperfusion arrhythmias by reducing intracellular calcium overload.”

“Deterioration of left ventricular ejection fraction was less severe after adenosine (72% +/- 5% before PTCA vs 64% +/- 6% during angioplasty; P =.11) and could be prevented by intracoronary dipyridamole (69% +/- 12% before PTCA vs 68% +/- 11% after PTCA; P <.”

“Objective Dipyridamole is a vasodilator that inhibits the cellular uptake of adenosine , which physiologically reduces the resistance to hepatic arterial flow inside the liver.”

“As a result, the total cost of using dipyridamole is significantly greater ($928.00 per patient) than the total cost of using adenosine ($672.00 per patient).”

“Urinary excretion of adenosine was significantly increased during infusion of dipyridamole.”

“ Dipyridamole , an adenosine uptake blocker, was expected to enhance the effect of endogenous adenosine.”

“ Dipyridamole 10 mg, an adenosine uptake blocker, enhanced the effect of adenosine by approximately 60%.”