Possible Interaction: Adenosine and Dinoprost

“It is concluded that adenosine enhances the steroidogenic response by functional bovine luteal cells to hCG, PGE1 or PGE2 and that adenosine reduces the luteolytic response to PGF2 alpha by gonadotropin-stimulated bovine luteal cells in vitro.”

“ PGF2 alpha inhibited the gonadotropic response to hCG, PGE1 or PGE2 (p less than 0.05) which was reduced by adenosine (p less than 0.05) by day 7 or 13 bovine luteal cell suspensions.”

“In rat luteal cells, adenosine blocked the acute antigonadotropic (luteolytic) action of PGF2 alpha.”

“Our data show that PGF2 alpha-induced rhythmicity in human coronary arteries could be inhibited by ouabain, alterations in K+ concentrations and by adenosine analogs.”

“ATP, 2‐methylthio ATP, α,β‐methylene ATP, β,γ‐methylene ATP, UTP and adenosine increased the output of PGF2α from guinea‐pig endometrium and myometrium after 24 h of culture, with a greater stimulatory effect being exerted on the endometrium than on the myometrium.”

“This study has investigated the effects adenosine 5′‐triphosphate (ATP), analogues of ATP, uridine 5′‐triphosphate (UTP) and … vitro, and from guinea‐pig endometrium and myometrium cultured for 24 h. ATP, 2‐methylthio ATP and adenosine … prostaglandin F2α (PGF2α) and 6‐keto‐PGF1α (reflecting … the superfused guinea‐pig uterus.”

“The addition of PGF2 alpha enhanced this tone which was similar to that obtained with a stretch of +35% Lo and no flow, whereas the effect of ADO was increased.”

“ACh, isoproterenol, histamine, 5-hydroxytryptamine, ATP and adenosine caused dose-dependent relaxations in the hepatic lymph vessels precontracted by 5 x 10(-6) M prostaglandin F2 alpha.”

“PGF2 alpha alone or in the presence of hCG decreased (P less than or equal to 0.05) the secretion …, PGF2 alpha decreased post treatment cell viability with or without hCG (P less than or equal to 0.05) and adenosine reduced (P less than … effect of PGF2 alpha ….”

“It is concluded that adenosine can block a PGF2 alpha-induced premature luteolysis in vivo and may have roles in regulation of luteal secretion of progesterone but it is probably not the embryonic antiluteolysin of early pregnancy in ewes.”

“ Adenosine , 5'-N-ethyl-carboxamide adenosine (NECA) and N6-L-phenyl-isopropyl adenosine (L-PIA) produced concentration-dependent relaxation of the coronary artery rings when precontracted with prostaglandin F2 alpha.”

“At all the concentrations tested, adenosine and its analogues [5'-(N-ethyl-carboxamidoadenosine, NECA; N6-(L-2-phenylisopropyl)adenosine, L-PIA] significantly inhibited prostaglandin F2 alpha-induced increases in calcium influx.”

“The data suggest that prostaglandin F2 alpha-induced calcium influx was more sensitive to the action of adenosine and its analogues than the calcium influx induced by high K+ depolarization.”

“The inhibition of calcium influx by adenosine , NECA, and L-PIA correlated well with their relaxing ability in the presence of prostaglandin F2 alpha.”