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Possible Interaction: Adenosine and Diazepam

supplement:

Adenosine

Research Papers that Mention the Interaction

Diazepam inhibits phosphodiesterase type 4 and enhances the effect of some 3′,5′-cyclic adenosine monophosphate (cAMP)-dependent positive inotropic drugs.
Anesthesia and analgesia  •  2006  |  View Paper
In order to reveal the possible role of inhibition of membrane adenosine transport in the effects of diazepam (a moderate inhibitor of membrane adenosine transport), the action of a 10-day treatment with dipyridamole or S-(p-nitrobenzyl)-6-thioinosine (NBTI; prototypic adenosine uptake inhibitors) was also studied.
Life sciences  •  1999  |  View Paper
…,diazepam (… adenosine on indirect twitch responses 3 The central type receptor agonist, clonazepam did not affect the inhibitory effect of adenosine 4 The peripheral benzodiazepine receptor … benzodiazepines potentiate the adenosine‐effected presynaptic inhibition of neuromuscular transmission by an inhibition of adenosine uptake through activation of peripheral type benzodiazepine receptors.
British journal of pharmacology  •  1995  |  View Paper
Diazepam … adenosine ; the maximal contractile effect of adenosine (% vs. acetylcholine 10(-3) M) was 20.4 +/- 4.2 (n = 21) in control conditions and 45.5 +/- …(-7) to 10(-5) M), both agonists of peripheral benzodiazepine receptors, potentiated the contractile effects of adenosine to the same extent as diazepam.
European journal of pharmacology  •  1992  |  View Paper
Dipyridamole (10−5 M) and diazepam (10−4 M) respectively produced a 56.2 and 32.4‐fold potentiation of adenosine relaxant effects.
Fundamental & clinical pharmacology  •  1991  |  View Paper
Added to the superfusion medium diazepam blocked responses to adenosine but not 5-HT; this effect was not observed with 2-chloroadenosine or in the presence of 2-hydroxynitrobenzylthioguanosine.
Brain Research  •  1990  |  View Paper
In a concentration (30 microM) virtually devoid of an effect on the …, twitch responses, or resting membrane potential of the muscle fibres, diazepam potentiated … adenosine on neuromuscular transmission, but not that induced by the stable analogue of … adenosine (NECA), which is not a substrate for the adenosine uptake system.
The results suggest that diazepam acts at the frog neuromuscular junction by increasing the level of adenosine at the junction level; this increase probably results from inhibition in the uptake of the nucleoside.
European journal of pharmacology  •  1989  |  View Paper
The inhibitory effect of adenosine but not that of 2-chloroadenosine was potentiated in the presence of diazepam.
European journal of pharmacology  •  1988  |  View Paper
Diazepam tended to potentiate negative chrono- and inotropic effects of adenosine but not significantly, suggesting that diazepam plays a minor role as an adenosine potentiator in the dog right atrium.
Archives internationales de pharmacodynamie et de therapie  •  1987  |  View Paper
Adenosine (10(-6) M) and ATP (10(-6) M) were degraded to inactive inosine during incubation with atrial segments and their degradation was inhibited by diazepam.
European journal of pharmacology  •  1985  |  View Paper
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