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Last Updated: 2 years ago

Possible Interaction: Adenosine and Dexmedetomidine

supplement:

Adenosine

Research Papers that Mention the Interaction

Moreover, dexmedetomidine inhibited cAMP-independent process formation induced by adenosine or the Rho-associated kinase inhibitor Y27632.
Journal of pharmacological sciences  •  2021  |  View Paper
At 100 μg/kg, dexmedetomidine increased adenosine concentration in plasma (0.23 ± 0.11 to 0.45 ± 0.07 μg/ml, P<0.05) and brainstem (1.46 ± 0.30 to 2.52 ± 0.22 μg/ml, P<0.05); such effect was blocked by atipamezole pretreatment.
These results suggest that dexmedetomidine enhances baroreflex sensitivity, possibly by increasing adenosine in NTS and α2-AR expression in astrocytes.
Brain Research  •  2020  |  View Paper