“At 100 μg/kg, dexmedetomidine increased adenosine concentration in plasma (0.23 ± 0.11 to 0.45 ± 0.07 μg/ml, P<0.05) and brainstem (1.46 ± 0.30 to 2.52 ± 0.22 μg/ml, P<0.05); such effect was blocked by atipamezole pretreatment.”
“These results suggest that dexmedetomidine enhances baroreflex sensitivity, possibly by increasing adenosine in NTS and α2-AR expression in astrocytes.”