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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Adenosine and Cyclosporine

supplement:

Adenosine

Research Papers that Mention the Interaction

Calculated peak values (tmax) of ADO were slightly delayed with respect to those of CsA and FK506.
Transplant international : official journal of the European Society for Organ Transplantation  •  2005  |  View Paper
Conversely, in the presence of CsA (500 and 1000 ng/ml), the uptake of ADO by erythrocytes was significantly decreased in adenosine deaminase-free samples (analysis of variance, P = 1.8.10(-3) and 1.2 x 10(-4), respectively).
In CsA-treated KTR, CsA and ADO plasma levels were significantly correlated (Spearman's, r = 0.8, P = 1.9 x 10(-3)).
We conclude that ADO plasma levels are significantly elevated and correlate with CsA blood level in CsA-treated KTR, and that these high levels are due to CsA inhibition of ADO uptake by red cells.
Kidney international  •  1998  |  View Paper
CsA 15mg/kg induced a statistically significant increase in ADP and decrease in adenosine (ADO) plasma levels compared to control group.
In conclusion, blood ecto-nucleotidases activity, tHcy, and ADP and ADO levels may be implicated in vascular injury induced by CsA treatment.
Chemico-biological interactions  •  2010  |  View Paper
The immunosuppressants, cyclosporin A and tacrolimus (FK506) induce an increase in plasma levels of adenosine and mimic ischemic preconditioning.
European journal of pharmacology  •  2001  |  View Paper
Previous reports have demonstrated that Cyclosporine A (CyA) chronically administered induces an increase in adenosine plasma concentration by inhibiting adenosine uptake by red blood cells (RBC).
Life sciences  •  1999  |  View Paper
Adenosine caused an increase in CBF in the LAD averaging 20 +/- 10 mL/min before CSA , 10 +/- 8 mL/min after CSA, and 17 +/- 12 mL/min during L-arginine injection (P = .004).
Circulation  •  1996  |  View Paper
Cyclosporine CSA ) caused a prompt and severe ATP depletion in both T and B cells, which could be mitigated by the addition of adenosine.
Surgery  •  1984  |  View Paper