Possible Interaction: Adenosine and Cromolyn

“ Adenosine antagonism could be considered as a possible factor contributing to the pharmacologic efficacy of sodium cromoglycate in asthmatic patients.”

“Flare produced by all ID agents, except adenosine , bupivacaine and lidocaine, was reduced by cromolyn.”

“ Adenosine- and AMP-induced bronchoconstriction are both blocked by cromolyn sodium and nedocromil sodium, with the PD20FEV1 for the latter approximately four times lower than that of cromolyn sodium in atopic asthmatic patients and approximately 2.3 times lower than that of cromolyn sodium in nonatopic asthmatic patients.”

“In asthmatic, but not normal, subjects, inhalation of adenosine causes a marked bronchoconstriction which may be reduced by the purinoceptor antagonist theophylline, sodium cromoglycate , nedocromil sodium, histamine, H1-antagonists and cyclo-oxygenase inhibitors.”

“The bronchoconstrictor response to adenosine was blocked selectively by methysergide, disodium cromoglycate and the broad‐spectrum adenosine receptor antagonist, 8‐SPT, but not by DPCPX or ZM 243185, selective antagonists for the A1 and A2A receptors, respectively.”

“The extravasation induced by adenosine in sensitized rats was dose dependently inhibited by SCG aerosols, SCG likewise inhibited microvascular responses to substance P, but had no effect on those to platelet-activating factor.”

“Depletion of granular components via stunning, compound 48/80, cold superfusate, or inhibition of secretion with cromolyn results in unopposed A1- or A2-mediated vasodilation in response to adenosine , whereas the dilatory effects of adenosine are blunted by simultaneous release of vasoconstrictors from mast cells in control animals.”

“The bronchoconstriction caused by adenosine is inhibited by atropine, methysergide, sodium cromoglycate , nedocromil sodium, and ketotifen.”