Possible Interaction: Adenosine and Corticosterone

“These results suggest that adenosine promotes secretion of corticosterone from the adrenal glands, which causes hepatic glycogenolysis and subsequently the elevation of blood glucose levels.”

“ Adenosine attenuated the elevation of corticosterone and altered expression of SLC5A1, NPC1L1 and TNF-α.”

“ Adenosine was found to alleviate HFD-induced increase in glucose and insulin levels, suppress elevation of corticosterone in S rats and improve the altered nutrient transporters expression profiles.”

“ Adenosine … corticosterone production in a time- and dose-dependent manner, and this adenosine effect was mediated by the A2 adenosine receptors, since the antagonists specific for … A2A and A2B adenosine receptors, and specific silencing the A2A adenosine receptor expression with small interfering RNA significantly blocked the adenosine-induced steroidogenesis.”

“ Adenosine , adenine and allopurinol, an inhibitor … oxidase, stimulated the synthesis of corticosterone , but their maximal effects were only about one tenth that of ACTH or c-AMP.While inosine and hypoxanthine, … not xanthine, inhibited the basal synthesis of corticosterone, all three compounds increased the ACTH- or DBA-stimulated steroidogenesis.”

“Added in vitro, adenosine reduced both adrenal basal and adrenocorticotropic hormone (ACTH)-stimulated corticosterone release, while it stimulated pituitary ACTH release.”

“ Adenosine caused a significant increase in the rate of perfusate flow through the adrenal, with a concomitant rise in corticosterone , but not aldosterone, secretion.”

“The intravenous … mg of adenosine 3′,5′-monophosphate (3 ′,5 ′-AMP), N6-2 ′-O-dibutyryl-3 ′,5 ′-adenosine monophosphate (dibutyryl 3′,5′-AMP) or 2′-…′,5′-adenosine monophosphate (monoacetyl 3′,5′-AMP) for 12 min caused a significant increase in adrenal corticosterone secretion in hypophysectomized rats, … had no effect.”

“Haynes, Koritz and Péron4 demonstrated that adenosine-3′,5′-monophosphate (cyclic 3′,5′-AMP) enhanced the production of corticosterone from endogenous precursors by surviving rat adrenal sections.”