Possible Interaction: Adenosine and Cordycepin

“The synergistic formation of cordycepin and adenosine or differences in metabolized pathways are a great possibility according to the same trend.”

“We show here in RAW264 cells that (a) the incorporation of the methyl group of methionine into phosphatidylcholine is … and 3-deazaaristeromycin, (b) 3-deazaadenosine but not 3-deazaaristeromycin inhibits the synthesis of specific proteins, and (c) 3'-deoxyadenosine and erythro-9-(… presence of adenosine and homocysteine … specific proteins.”

“ Cordycepin was more potent than xylosyladenine in inhibiting 2′-0-methylation of cytidine and adenosine , but not guanosine.”

“The effect of cordycepin on both accumulation of cordycepin phosphates, decrease in ribotide pool, and inhibition of incorporation of [ 32 P]P i into the nucleic acids may be prevented by simultaneous addition of adenosine.”

“A positive weak correlation between the cordycepin and adenosine contents was observed with a Pearson correlation coefficient of 0.338 (P < 0.05).”

“For the mutant strain, the optimum dose of adenosine yielded a 30% increase in cordycepin production ; the maximum levels of production with adenosine and without adenosine were 8.6g/l and 6.7 g/l, respectively.”

“ Adenosine down-regulated the gene expression of M1 cytokines (IL-1β, TNF-α) and chemokines (CX3CR1, RANTES), as well as cordycepin.”

“The incorporation of [3H]adenosine into RNA was inhibited by cordycepin within 10 min.”