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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Adenosine
supplement:
Cobaltous Cation
Research Papers that Mention the Interaction
“ Ado accumulation was enhanced in the presence of Co2+ ion and inhibited by EDTA, further supporting the involvement of a metallo-phosphatase such as 5’-NT in extracellular AMP conversion into Ado.”
Release of Periplasmic Nucleotidase Induced by Human Antimicrobial Peptide in E. coli Causes Accumulation of the Immunomodulator Adenosine“Recording intracellularly from hippocampal CA3 pyramidal cells we show that Co2+ (2 mM) is not specific in this action but also diminishes postsynaptic responses mediated by agonists acting at ionotropic and metabotropic glutamatergic receptors, as well as GABAA, GABAB, adenosine , and cholinergic receptors.”
Cobalt blocks postsynaptic responses induced by neurotransmitters in the hippocampus in vitro“ Co2+ , Ni2+ and La3+ markedly stimulated specific C1[3H]Ado binding by 45-150% above control when tested at concentrations of 1-10 mM. Ca2+ had no significant effect on binding except at high concentrations where it depressed binding slightly.”
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